Adhering to the concept of "driving clinical transformation through cutting-edge basic research", the Clinical Medicine Institute is committed to building a clinical medical innovation highland that is based in Hangzhou, radiates across the country, and faces the world. Through mechanism innovation and disciplinary integration, it explores a new paradigm of "research-driven, clinical collaboration, and AI-enabled", creating a focused, inclusive, and long-term academic ecosystem to provide original innovative forces for conquering major diseases. It will implement an internationalized "physician-scientist" training model and PI responsibility system, relying on the rich clinical resources in the Yangtze River Delta, deeply integrating with multiple top hospitals, and building a rapid "clinical - basic - clinical" transformation channel from the end to the beginning, with a focus on cultivating medical leading talents and innovative teams with an international perspective.