Dr. Wang is a senior scholar who began his career in optical research and later transitioned to interdisciplinary studies in physics and life sciences. He served as the inaugural Director of the Lab of Soft Matter and Biological Physics at the Institute of Physics, Chinese Academy of Sciences. He investigated dynamic behaviors and chaotic phenomena in liquid crystals and optical systems, and developed the spatial perturbation method to control pattern formation, spatiotemporal chaos, and spiral waves in nonlinear systems. He also investigated spatiotemporal dynamics in excitable systems. His research includes single-molecule DNA melting and condensation, DNA–histone interactions, dynamics of biomolecular motors including helicases, motor proteins, and myosins. He investigated interactions between anticancer drugs, including cisplatin, and DNA, and proposed the SLSC (softening–looping–shortening–condensation) model to describe cisplatin-induced conformational changes in DNA. He studied nucleosome assembly and regulation by using single-molecule magnetic tweezers, the effects of paclitaxel on epidermal growth factor receptor (EGFR) endocytic trafficking in living cells, intracellular diffusion and transport of quantum dots, and the “gear-shifting” dynamics of cell migration. He has published over 200 papers in top-tier journals, including Nature, PNAS, PRL, and JACS, and has been awarded the special government allowances of the State Council. He has also secured funding from the National Science Fund for Distinguished Young Scholars, key projects, and major research initiatives.

He anticipates two major directions for collaboration: surface physics and super-resolution optical microscopy (including ultraviolet and X-ray wavelengths). Collaboration in surface physics will leverage advanced techniques such as ultrafast Raman spectroscopy and scanning tunneling microscopy (STM) to investigate interactions between biological systems and various surfaces at atomic and molecular levels, addressing fundamental issues in biochips and medical materials. Collaboration in super-resolution optical microscopy will enable in vivo dynamic observation of living cells and organoids with label-free ultra-high spatial and fast temporal resolution, allowing in situ study of biomacromolecular interaction dynamics within cells and organelles to reveal the essence of life. It also permits observation of intercellular interactions within organoids and interactions between cells and other surfaces, providing critical insights for life science and medical questions such as cell differentiation and immune responses.